Confidence Through Evidence
At Cogniguard we are committed to delivering science-based, clinically-validated therapy for MCI and early Alzheimer’s patients. Our team of neuroscientists, clinicians and Biomedical engineers has spent years developing and refining the Vguard solution. During night sleep, Vguard delivers special neurostimulation treatment, proven in an animal study model, to generate Theta Waves, which have been shown to reflects Hippocampal activity. This innovative approach enhances cognitive function, preserves memory, and slows the progression of cognitive decline.
Promising Clinical Results in early-stage clinical studies. Publications underway
fMRI during Vguard stimulation
DATA ON FILE
In a case study, Vguard auricular vagal stimulation was found to activate specific brain regions linked to cognitive functions, as demonstrated by functional MRI (fMRI) scans. The activation patterns, highlighted by yellow and orange regions in the fMRI images, indicate neural engagement in areas critical for cognition.
Hippocampus Activation – Animal model
The company established the device’s mechanism of action through fundamental research in animal, demonstrating a direct link between electrical stimulation of the vagus nerve and cognitive arousal.
In these studies, it was demonstrated for the first time the presence of hippocampal type II theta in response to the application of VNS.
This discovery is groundbreaking in showing the impact of VNS stimulation on hippocampal function, a key brain structure responsible for memory processing.
The research enabled the development of a stimulation protocol used in the VGuard method. The results of our studies have been published in a series of research papers in renowned scientific journals.
References:
Brain Research 1675, November 2017, Pages 41-50
Brain Res Bull. 147, Apr 2019, pages 110-123
Brain Res Bull. 152 Oct 2019, pages 236-245
Theta II activity of hippocampal formation in response to VNS
